Tuesday, June 21, 2022

Lockdowns led to a global mental health crisis in children, says World Health Organization report

Covid lockdowns have caused a 'global mental health crisis' in children due to 'deep impact of school closures', WHO admits | MailOnline - Joe Davies: 

June 20, 2022 - "Covid lockdowns have created a 'global crisis for mental health', the World Health Organization has admitted. An international report by the UN agency found two years of restrictions have led to 'significant mental health consequences', especially for young people. The WHO now estimates more than a billion people around the world are living with a mental health disorder as a result, a quarter more than pre-Covid. It said there had been an even bigger rise among children, 'potentially reflecting the deep impact of school closures'....

"The WHO World Mental Health Report was published on June 16 by the WHO's mental health and substance division.... It said more than one billion people are now living with a mental health condition, after increasing by more than 25 per cent dung the first year of the pandemic. The most common types include anxiety, depression and developmental disorders like autism. But children were worst affected by restrictions, officials said, with rates of bullying and abuse at home increasing and a lack of social interaction causing isolation during school closures. 

"The report said: 'Restrictions imposed during the Covid pandemic for example had significant mental health consequences for many, including stress, anxiety or depression stemming from social isolation, disconnectedness and uncertainty about the future.' It added: 'Globally there was also a greater change in prevalence among younger age groups than older ones, potentially reflecting the deep impact of school closures and social restrictions on youth mental health.... For some children and adolescents, being made to stay at home is likely to have increased the risk of family stress or abuse, which are known risk factors for mental health problems.' 

"The WHO's mental health and substance division is responsible for helping prevent mental, neurological and substance use disorders and was not in charge of the WHO's Covid response. It was signed off by Dr Tedros Adhanom Ghebreyesus, director general of the WHO, who faced heavy criticism for his handling of the pandemic, which was deemed to be very 'China-centric', heaping praise on China's communist party for its response to the Covid outbreak.... But he has since been censored by Chinese state media for criticising the country's current zero Covid policy in May this year.... 

"Before the pandemic, the WHO estimated as many as one in seven (14 per cent) of children had a mental health disorder. The report did not estimate the current rate but said the 25 per cent increase in disorders across the world was even higher in children. It said: 'Extended school and university closures interrupted routines and social connections, meaning that young people missed out on learning and experiences expected for healthy development.... Disruption and isolation can fuel feelings of anxiety, uncertainty and loneliness, and can lead to affective and behavioural problems.' 

"Boris Johnson closed England's 24,000 schools for the first time in March 2020, with some children returning briefly from June that year. Classes were then shut again in January 2021 at the start of the Alpha wave before reopening on March 1. Overall, schools in England were shut for longer than in any other European country. Several studies since then have shown young people's mental health deteriorated while learning at home. A study led by University College London researchers showed nearly five times as many children died of suicide compared to the virus during the first year of lockdowns....

"[The WHO report] comes after a new book claimed ministers ignored warnings that continued school closures would cause an upswing in mental health problems for children. The book, written by the founders of the UsForThem campaign, revealed Anne Longfield, then Children’s Commissioner, spent ‘weeks and weeks’ arguing that children should return to school.... Ms Longfield told the authors it was ‘absolutely unnecessary’ to keep schools closed until the last weeks of the summer term in 2020. She said: ‘It added a huge additional detriment to those children and was completely irresponsible and virtually criminal for those children.’"

Read more: https://www.dailymail.co.uk/news/article-10933827/Covid-lockdowns-caused-global-crisis-mental-health-children-school-closures.html

Download Report: https://www.who.int/publications/i/item/9789240049338

Monday, June 20, 2022

Vets 4 Freedom plan summer of Ottawa protests

Freedom Convoy protesters set to return to Ottawa for Canada Day, stay through summer | CBC News - David Fraser:

June 17, 2022 - "Ottawa police say they expect more protests and larger than usual crowds during Canada Day celebrations in the capital this July as groups related to the Freedom Convoy continue to plan protests.... Significant road closures and an increased police presence are expected. Police say additional resources from other services are being brought in....


James Topp. Photo: Rebel News

"Protests are expected to take place on a mass scale in the city starting June 30 when James Topp, a veteran marching across Canada in protest of the remaining vaccine mandates, plans to end his cross-country journey at the National War Memorial in downtown Ottawa. 

"Topp began walking to Ottawa in February, inspired by the convoy protests and disturbed, he said, by government overreach affecting people who have chosen not to get vaccinated against COVID-19.... 'This entire march, the purpose of it was to serve as a protest. I felt it was a violation in several different ways.' 

"Topp said there was no talk of dropping vaccine mandates when he started the protest. He intends on meeting with MPs once he arrives in Ottawa.... It's not known which MPs have agreed to speak with Topp.

"Topp's march is supported by Veterans 4 Freedom, one of the main groups responsible for organizing the Rolling Thunder protests that took place in April.  The group's steering committee includes Tom Marazzo, who also gained prominence during the convoy protests in Ottawa, at times acting as an official spokesperson for protesters. He also ran in the Peterborough-Kawartha riding for the Ontario Party during the recent provincial election. 

"Andrew MacGillivray, who co-founded Veterans 4 Freedom, says the group has been liaising with Ottawa police about Topp's arrival. He also noted events will continue into Canada Day. A route of Topp's march into the city is circulating online, and plans for a weekend of camping downtown near Parliament Hill are in the works. MacGillivray said the group wants to have the 'least impact on citizens of Ottawa with their everyday life.'"
Read more: https://www.cbc.ca/news/canada/ottawa/freedom-convoy-protesters-return-canada-day-1.6492504

‘Freedom movement’ rallies planned to run in Ottawa all summer: organizer | Eagle Valley News - Erika Ibrahim, Canadian Press:

June 17, 2002 - "Andrew MacGillivray, steering committee member for Veterans for Freedom, said in an interview posted on YouTube that it will hold a three-day conference in Ottawa next week, from Wednesday to Friday. Veterans for Freedom describes itself on its website as a group made up of Canadian veterans working to “restore fundamental freedoms for all Canadians” and “uphold Canadian laws.” The organization has partnered with other groups that oppose pandemic mandates, including those calling themselves Police on Guard and Canadian Frontline Nurses....

"MacGillivray said the group’s aim is to have the federal government repeal remaining mandates, reinstate federal workers who lost their jobs related to mandates and pay those workers for lost wages. He said his group plans to hold a meeting with up to 17 MPs on Wednesday, who are 'mostly Conservative,' and the next two days will be town hall events with key people in the 'freedom movement.'

"On June 30, Veterans for Freedom is co-ordinating a route for James Topp and his supporters to walk through parts of Ottawa to the National War Memorial. The route has received a police escort, said MacGillivray. Topp is a Canadian soldier who was charged by the Department of National Defence in May after publicly speaking out against federal vaccine requirements while in uniform. He left Vancouver in February to walk to Ottawa in protest of pandemic mandates, according to the Canada Marches website....

"MacGillivray said it will also set up a semi-permanent camp east of Ottawa called 'Camp Eagle' and will be holding events all summer. The camp sits about 40 minutes outside the city on private property. 'Basically, we’re going to stay there the entire summer. We’re going to implement our strategy and our plan to lean on the government through education, information, et cetera.'"
Read more: https://www.cbc.ca/news/canada/ottawa/freedom-convoy-protesters-return-canada-day-1.6492504

Sunday, June 19, 2022

Covid and the Medical-Industrial Complex

Covid Exposed the Medical-Pharmaceutical-Government Complex | Brownstone Institute - Mark Oshinskie:

Image: Salon, 2016.

June 18, 2022 - "In college, I took a Latin American Politics and Development class. When discussing Latin American medical care, Professor Eldon Kenworthy presented a deeply countercultural idea. Echoing a journal article by the scholar, Robert Ayres, Kenworthy maintained that building hospitals there costs lives. If, instead of erecting, equipping and staffing gleaming medical centers, this same money and human effort were devoted to providing clean water, good food and sanitation, the public health yield would be much greater. 

"United States medical history bears out Ayres’s paradox. The biggest increases in US life expectancy occurred early in the Twentieth Century, when people had increasing access to calories and protein, better water and sanitation. Lives lengthened sharply decades before vaccines, antibiotics or nearly any drugs were available, and a century before hospitals merged into corporate Systems. Incremental American life span increases during the past fifty years reflect far less smoking, safer cars and jobs, cleaner air and less lethal wars more than they reflect medical advances. Books like Ivan Illich’s Medical Nemesis and Daniel Callahan’s Taming the Beloved Beast echo Ayres’s critique. But PBS, CNN, B & N [Barnes & Noble], the NYT [New York Times], et al. censor such views.

"The American medical landscape has changed radically in the forty years since I learned of Ayres’ observation. America spends three times as much, as a percentage of GDP, on medical treatments as it did in the 1960s. By 2020, America devoted 18% of its GDP to medicine. (By comparison, about 5% goes to the military). Adding the mega-costs of mass testing and vaccines etc., medical expenditures might now approach 20%. Although the US spends more than twice per capita what any other nation spends on medical care, American ranks 46th in life expectancy. US life expectancy has flatlined, despite growing medical spending and broadened medical access via the vaunted Affordable Care Act. 

"Though medicine’s high-cost and relatively low yield are right in front of anyone who thinks about their medical experiences and those of people they know, most never connect the dots; more medical treatments and spending are continually advocated and applauded. There’s a regressive 'if it saves — or even slightly extends — one life' medical zeitgeist/ethic.

"As most medical insurance is employer-based, most people don’t notice annual premium increases. Nor do they see the growing slice of tax revenues used to subsidize Med/Pharma. Thus, they continually demand more stuff, like IVF, extremely high-cost drugs, sex changes or psychotherapy, as if these were their right, and free. To say nothing of these treatments’ limited effectiveness. As all are required to medically insure and to pay taxes, one can’t simply opt out or buy only those medical services that one thinks justify their costs. With massive, guaranteed funding sources, aggregate medical revenues will continue to climb. 

"Th[e] Medical-Industrial-Government Complex has become a Black Hole for today’s wealth. With great money comes great power. The Med/Pharma juggernaut rules the airwaves. Nonexistent until the 1990s, hospital System and drug ads now dominate advertising. By being such big advertisers, Med/Pharma dictates news content. Analysts who point out that lavish medical expenditures don’t yield commensurate public health benefit have small audiences. Med/Pharma critics can’t afford ads. 

"Medicine has fed Coronamania. The TV news I’ve seen during the past 27 months painted a very skewed picture of reality. The virus has been misrepresented — by the media and government, and by MDs, like Fauci, often posing in white jackets — as a runaway train that’s indiscriminately decimating the American populace. Instead of putting into perspective the virus’s clear demographic risk profile and the very favorable survival odds — even without treatment, at all ages, or promoting various forms of contra-Covid self-care, including weight loss — the media and medical establishment incited universal panic, and promoted counterproductive mass isolation, mass masking, mass testing, and treatment with ventilators and expensive, often harmful anti-virals. 

"Later, mass injections were added to the 'Covid-crushing' armamentarium. While the shots created many billionaires, and greatly enriched other Pfizer and Moderna stockholders, they failed, as Biden and many others had promised, to stop either infection or the spread. All of the many whom I know who have been infected in the past six months were vaxxed. 

"Many — whose voices are suppressed by mainstream media — [contend] that the shots have worsened outcomes, by driving the development of variants, weakening or confusing immune systems, and causing serious near-term injuries. Further, people blindly, ardently believed in the shots simply because they were marketed as 'vaccines' by bureaucrats wearing medical garb. Despite the shots’ failure and the failure of other 'mitigation' measures like lockdowns, masking and testing, many refuse to concede that Med/Pharma has had much — overwhelmingly negative — influence over the society and economy and public health during Coronamania. Nonetheless, many billions of dollars have been — and are still being — spent to advertise shots that most people don’t want. 

"The Covid overreaction has to some extent also piggy-backed on TV programs that have, for decades, glorified medicine in TV shows like Dr. Kildare, Marcus Welby, M.D., Medical Center, MASH, Gray’s Anatomy and House. Wearing white coats connotes virtue, just as did wearing white hats in Western movies. Given the cumulative PR onslaught of the ads and shows, medicine is widely seen as more effective than it is in real life....

"Medicine is the new American religion. Given such fervent belief in medicine’s importance and the sense of entitlement regarding expanding medical treatments, government and insurance money is relentlessly overallocated to medicine. Do these expenditures improve human outcomes? 

"During the first Scrubs episode, resident J.D. complains to his mentor that being a doctor was different than he had envisioned; most of his patients were 'old and kind of checked out.' His mentor responds, 'That’s Modern Medicine: advances that keep people alive who should have died a long time ago, back when they lost what made them human.' This largely describes those said to have died with Covid. Most people have disregarded that nearly all who died during the pandemic were old and/or in poor health. Most deaths have always occurred among the old and ill. Occasionally, sitcoms keep it realer than real people do.

"Aside from not helping much and misspending resources, and extending misery, medicine can be iatrogenic, i.e., it can cause illness or death. Hospital errors are said to cause from 250,000 to 400,000 American deaths annually. Perhaps medical personnel try to do a good job. but when the bodies of old, sick people are cut open or dosed with strong medicine, stuff happens. Even well-executed surgeries and many medications can worsen health. 

"Further, though few know it, a brew of excreted medications and diagnostic radionuclides daily pours down drains across the US and world and ends up in streams and rivers. For example, the hormones in widely-prescribed birth control pills feminize and disrupt aquatic creatures’ reproduction. There are books about all of this, too, though such authors never appear on Good Morning America

"Faith in medical interventions also lessens individual and institutional efforts to maintain or improve health. If people didn’t abuse substances, ate better and moved their bodies more, there would be much less demand for medical interventions. And if people spent less time working to pay for medical insurance, they could spend more time taking care of themselves and others. Overall, America could spend a fraction of what it spends on allopathic medicine and yet, be much healthier. There are also plenty of books about this. 

"Given its place at the center of American life for 27 months, and counting, Covid has been — and will be — used to further intensify the medicalization of individual lives, the economy, and society. By exploiting and building an irrational fear of death, the Medical Industrial Complex will promote the notion that we should double — or triple — down on medical and social interventions and investments that might marginally extend the lives of a small slice of the population. Or, in many instances, shorten lives. But most people who live sensibly are intrinsically healthy for many years. Given enough nutritious food, clean water and a decent place to sleep, most people will live a long time, with little or no medical treatment. While intensive medical interventions can marginally extend the lives of some old, sick people, medicine can’t reverse aging and it seldom restores vitality. 

"If the media were honest brokers, the Covid mania would never have taken hold. The media should have repeatedly pointed out that the virus only threatened a small, identifiable segment of a very large population. Instead, captive to its Med/Pharma sponsors, the media went full-frontal fearmonger and promoted intensive, society-wide intervention. Social, psychological and economic catastrophe ensued. Additionally, many doctors who could have spoken against the Covid craziness stayed silent so as not to jeopardize their licenses, hospital privileges or favored status with Pharma, or just because they were schooled in allopathic orthodoxy and hold fast to that faith. Props to those courageous few who broke ranks. 

"The Med/Pharma/Gov establishment, including the NIH and CDC, hasn’t saved America during 2020-22. To the contrary, Covid interventions have worsened overall societal outcomes. These net harms should have inflicted — and, depending on longer-term vaxx effects, may yet inflict — a big black eye on the Medical Industrial Complex." 

Read more: https://brownstone.org/articles/covid-exposed-the-medical-pharmaceutical-government-complex/

This work is licensed under a Creative Commons Attribution 4.0 International License.

Saturday, June 18, 2022

Canadians' trust in media falls to new low


June 15, 2022 - "Canadians’ trust in the legacy media has reached a new low, according to a report from the Reuters Institute and the University of Oxford. The loss in media trust shown by the 2022 Digital News Report was mainly among anglophone Canadians, with francophones having higher trust levels in legacy outlets. Only 39% of anglophone Canadians said they 'trust most news,' a 16% drop from 2016. Meanwhile, 47% of francophones 'trust most news,' an 8% drop from 2016. The combined rating of Canadians trusting 'most news' equates to 42%, a 13% drop since 2016.

"The report also suggests fewer Canadians are using many major legacy media outlets’ online platforms. Compared to 2016, 5% less of anglophones use CBC’s online platform and 3% less use CTV News’. The study also found fewer Canadians were using Global, Buzzfeed and CNN’s online news platforms. CBC News, the Toronto Star and CP24 are the anglophone Canadian outlets with the highest amounts of distrust. Canadians also considerably distrust American media outlets including CNN, The New York Times and Fox News.

"According to the report, less Canadians also believe that the legacy media is independent and free of political or business influence. Only 27% percent of anglophone Canadians believe the media is not politically influenced, down 17% from 2016. The figure held up at 38% for francophones, making for a combined trust rating of 29%.

"The study also found that trust in the legacy media is lower among younger people, with those under 35 showing greater scepticism. Further, the study found viewers are avoiding legacy media outlets altogether. According to the study, 71% of people are avoiding the legacy media, a 16% increase from 2017. Many respondents cited the legacy media’s Covid-19 and political coverage as well as negative impacts on mental and physical health as reasons for tuning out of the media....

"The Digital News Report 2022 was conducted while the Freedom Convoy demonstrations were taking place in Ottawa. Many observers accused the legacy media of having a bias against the convoy, after many claims made by the legacy media about the movement were proven to be wrong. The CBC, for example, had to retract two stories related to the convoy.

"Despite fewer Canadians tuning into legacy media outlets, the Trudeau government has committed millions to bail out media outlets and increased funding to the CBC – another possible factor in the loss of legacy media trust.

"A survey by the public relations firm Edelman had also found a loss Canadians’ trust in the legacy media, with 61% of respondents saying they believed journalists are 'purposely trying to mislead people by saying things they know are false or gross exaggerations,' which was up 12% from the previous year."

Friday, June 17, 2022

Vax mandates for thee, but not for thy MP

Canada's House of Commons has unanimously agreed to suspend Covid vaccine mandates -- on the House of Commons. 

House of Commons to suspend COVID-19 vaccine mandate for MPs, staff, visitors | Global News - Sarah Ritchie, Canadian Press:

June 16, 2022 - "The House of Commons has unanimously agreed to suspend COVID-19 vaccine mandates for MPs [Members of Parliament], staff and visitors starting on Monday. Government House leader Mark Holland put forward a motion Thursday afternoon to end the mandate, which has been in place since last fall, after house leaders from all parties met earlier this week.... This week the federal government also announced it is suspending vaccine mandates for domestic and outbound international flights and rail travel starting Monday.

"The Board of Internal Economy, an all-party committee that makes decisions about Parliament business, voted to bring in a vaccine mandate for anyone coming to the remainder of the parliamentary precinct beginning last November. It has also decided to suspend that mandate beginning Monday. Wearing masks is still mandatory in the House of Commons until June 23, and that rule will stay in place for the rest of the precinct until then, board chair and House Speaker Anthony Rota said in a statement.

"Brassard said he expects that on Monday, every MP will be in their seat in the House of Commons. That hasn’t been the case for every Conservative MP this sitting, as some have refused to disclose their vaccination status. That includes Saskatchewan MP Cathay Wagantall, who recently said she was required to leave the precinct, and that she hasn’t been able to access her office since the rules took effect. 

"Brassard wants another rule change: 'This theatrical mask-wearing thing has to end.... If somebody wants to wear a mask on Parliament Hill, and they feel comfortable that they need to wear a mask, then they should wear a mask. If somebody doesn’t want to wear a mask, then they shouldn’t wear a mask.'

"June 23 is the last scheduled day of the sitting before Parliament takes its summer break. Negotiations are ongoing between the parties about what will happen as the fall sitting begins in September. It’s not yet clear if vaccines will be required, if masks will need to be worn, or if the House will still have hybrid sittings."

Read more: https://globalnews.ca/news/8926579/house-of-commons-covid-vaccine-mandate-ending/

Thursday, June 16, 2022

World Health Org wants Covid's origin investigated

WHO reverses stance to recommend deeper probe of coronavirus origins in China. China insists lab-leak theory is a lie | MarketWatch - Ciara Linnane:

June 10, 2022 - "The World Health Organization [WHO] has reversed its stance on the origins of the coronavirus pandemic and is now recommending a deeper probe into whether it was caused by an accident in a laboratory in China. Coming more than two years after the virus was first detected in Wuhan, and after at least 6.3 million deaths worldwide, the move may surprise critics who accused the agency of being too quick to dismiss or downplay the lab-leak theory that put Chinese officials on the defensive....

"Just last year, the WHO said it was 'extremely unlikely' that COVID came from a lab, and more likely it jumped to humans from an animal such as a bat. In March 2021, WHO released a report about COVID-19’s origins following a highly choreographed visit by international scientists to China. 

"Now in a report released Thursday, WHO’s expert group said 'key pieces of data' to explain how the pandemic began were still missing. The scientists said the group would 'remain open to any and all scientific evidence that becomes available in the future to allow for comprehensive testing of all reasonable hypotheses.' Jean-Claude Manuguerra, a co-chair of the 27-member international advisory group, acknowledged that some scientists might be 'allergic' to the idea of investigating the lab-leak theory but said they needed to be 'open minded' enough to examine it.

"Investigations by the Associated Press found that some top WHO insiders were frustrated by China during the initial outbreak even as WHO heaped praise on Chinese President Xi Jinping. They were also upset over how China sought to clamp down on research into the origins of COVI9.

"WHO Director-General Tedros Adhanom Ghebreyesus sent two letters to senior Chinese government officials in February requesting information, including details about the earliest human cases of COVID-19 in the city of Wuhan. It’s unclear whether the Chinese responded. The experts said no studies were provided to WHO that assessed the possibility of COVID-19 resulting from a laboratory leak.

"China responded Friday by calling the lab-leak theory a politically motivated lie.... Foreign Ministry spokesperson Zhao Lijian also rejected accusations that China had not fully cooperated with investigators.... Zhao also called for an investigation into 'highly suspicious laboratories such as Fort Detrick and the University of North Carolina' in the United States, where China has suggested, without evidence, that the U.S. was developing the coronavirus as a bioweapon."

Read more: https://www.marketwatch.com/story/who-reverses-stance-to-recommend-deeper-probe-of-coronavirus-origins-in-china-china-says-lab-leak-theory-is-a-lie-11654865073

Wednesday, June 15, 2022

Scientists develop test to measure T-cell immunity

How strong is your Covid immunity? A blood test could offer some insight | NBC News - Denise Chow:

June 14, 2022 - "A newly developed blood test that measures a specific immune response in the body could help doctors gauge how much protection a person has against Covid-19, according to a new study. The test, which focuses on the part of the immune system that confers long-term protection by prompting the body to 'remember' the virus, could help make sense of the complex tangle of Covid immunity that now exists from person to person.

"The test can, for instance, measure immunity regardless of whether someone has developed a level of protection from one or more natural infections ["natural immunity"] or from vaccinations and booster shots. Others, who may have much lower levels of protection because they are immunocompromised, could also use the test to assess their vulnerability and see how they responded to the vaccines, said Ernesto Guccione, an associate professor of oncological sciences and pharmacological sciences at the Tisch Cancer Institute at Mount Sinai. 'Ideally, it will give you a full picture of where you stand and a comprehensive picture of your immune protection,' said Guccione, one of the authors of the study published Monday in the journal Nature Biotechnology....

"The test involves taking a small blood sample at a clinic and mixing it with snippets of proteins from the virus. Researchers then look to see if the so-called T cells are activated in the sample. T cells are the cornerstone of the immune system's long-term memory and typically lie in wait until they detect the presence of foreign invaders. Unlike antibody levels, which can wane following vaccinations or infections, T cells can recall a virus years, and sometimes decades, later.... T cells are primed to 'recall' fragments of a virus, including from variants that can dodge protective antibodies.... T cells won't stop an infection from happening, but they can prevent a patient from becoming severely ill from Covid. 

"Previous studies have found that T cells can recognize all the known variants of concern, including omicron, but Guccione said it's an active area of research.... Tests to detect T cells have mostly been limited to labs for research purposes, and the process is usually expensive and difficult to do on a large scale, Guccione said. The new kit, however, is designed to be used widely, and results can typically be delivered in less than 24 hours, he added.... 

"Currently, the test can detect the activation of T cells, but the researchers are hoping that subsequent versions may be able to provide more granular detail, said Jordi Ochando, an assistant professor of oncological sciences at the Icahn School of Medicine at Mount Sinai and one of the study co-authors.... Future iterations may, for example, be able to provide details on the magnitude and the duration of a person's immunity to Covid. Each test costs roughly $50 to run, but Ochando said it's possible that companies that license the product could include a markup on the price.

"The test was developed by researchers at Mount Sinai and the Duke-NUS Medical School in Singapore. It is commercially available in Europe, as part of a licensing agreement with Hyris, a biotechnology company based in the United Kingdom."

Read more: https://www.nbcnews.com/science/science-news/much-covid-immunity-figuring-crucial-complicated-rcna13774

Read study: https://www.nature.com/articles/s41587-022-01347-6