Coronavirus: Dexamethasone proves first life-saving drug | BBC News - Michelle Roberts, Health Editor:
June 16, 2020 - "The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, UK experts say. The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus. It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.
"Had the drug had been used to treat patients in the UK from the start of the pandemic, up to 5,000 lives could have been saved, researchers say. And it could be of huge benefit in poorer countries with high numbers of Covid-19 patients. The UK government has 200,000 courses of the drug in its stockpile and says the NHS will make dexamethasone available to patients.
"About 19 out of 20 patients with coronavirus recover without being admitted to hospital. Of those who are admitted, most also recover but some may need oxygen or mechanical ventilation. And these are the high-risk patients dexamethasone appears to help.... [I]t appears to help stop some of the damage that can happen when the body's immune system goes into overdrive as it tries to fight off coronavirus. This over-reaction, a cytokine storm, can be deadly.
"In the trial, led by a team from Oxford University, about 2,000 hospital patients were given dexamethasone and compared with more than 4,000 who were not. For patients on ventilators, it cut the risk of death from 40% to 28%. For patients needing oxygen, it cut the risk of death from 25% to 20%.... The treatment is up to 10 days of dexamethasone and ... essentially it costs £35 to save a life."
Read more: https://www.bbc.com/news/health-53061281
June 16, 2020 - "The low-dose steroid treatment dexamethasone is a major breakthrough in the fight against the deadly virus, UK experts say. The drug is part of the world's biggest trial testing existing treatments to see if they also work for coronavirus. It cut the risk of death by a third for patients on ventilators. For those on oxygen, it cut deaths by a fifth.
"Had the drug had been used to treat patients in the UK from the start of the pandemic, up to 5,000 lives could have been saved, researchers say. And it could be of huge benefit in poorer countries with high numbers of Covid-19 patients. The UK government has 200,000 courses of the drug in its stockpile and says the NHS will make dexamethasone available to patients.
"About 19 out of 20 patients with coronavirus recover without being admitted to hospital. Of those who are admitted, most also recover but some may need oxygen or mechanical ventilation. And these are the high-risk patients dexamethasone appears to help.... [I]t appears to help stop some of the damage that can happen when the body's immune system goes into overdrive as it tries to fight off coronavirus. This over-reaction, a cytokine storm, can be deadly.
"In the trial, led by a team from Oxford University, about 2,000 hospital patients were given dexamethasone and compared with more than 4,000 who were not. For patients on ventilators, it cut the risk of death from 40% to 28%. For patients needing oxygen, it cut the risk of death from 25% to 20%.... The treatment is up to 10 days of dexamethasone and ... essentially it costs £35 to save a life."
Read more: https://www.bbc.com/news/health-53061281
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